Extended-Release and Long Acting Opioid Analgesics Risk Evaluation and Mitigation Strategy (REMS)


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Re-envision the Future of ER/LA Opioids

Making a difference in opioid treatment

The goal of the PainEDU REMS Education Program is to help healthcare providers make better-informed decisions about their patients' pain care when Extended-Release/Long-Acting (ER/LA) opioid analgesics are an appropriate component of therapy. It aims to educate healthcare providers on how to safely prescribe ER/LA opioid analgesics to control pain while minimizing adverse effects and negative outcomes - most importantly, overdose and death.

The PainEDU REMS Education Program is a direct response to the FDA Risk Evaluation and Mitigation Strategy (REMS) and is sponsored and certified by Albert Einstein College of Medicine and Montefiore Medical Center, under the direction of Naum Shaparin, MD. and Kevin L. Zacharoff, MD. The course consists of 3 one-hour CME activities, totaling 3.0 AMA PRA Category 1 Credits, and focuses on the safe and effective management of pain with ER/LA opioid analgesics in accordance with the FDA Blueprint. The CME content is directed towards prescribers of ER/LA opioid analgesics, but is also relevant for other healthcare professionals.

The program was released on May 12th, 2014 and the termination date is May 12th, 2016.

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Topics covered in the CMEs include:

  • Fundamentals of Safe and Effective use of ER/LA Opioid Analgesics in the Management of Chronic Pain
  • Safe and Effective Management of ER/LA Opioid Analgesic Therapy
  • General Concepts and Information About ER/LA Opioid Analgesics
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This educational activity is supported by an independent educational grant from the ER/LA Opioid Analgesic REMS Program Companies. Please see for a listing of the member companies. This activity is intended to be fully compliant with the ER/LA Opioid Analgesic REMS education requirements issued by the US Food & Drug Administration.